Pubblicazioni Scientifiche in Ozonoterapia



Si allegano oltre 130 Pubblicazioni Scientifiche ( frutto di una revisione di circa 1000 lavori) sull’efficacia dell’Ozonoterapia nel trattamento di molte patologie in ambito medico.  Tali evidenze tengono conto inoltre della ” Dichiarazione di Madrid sull’Ozonoterapia”  del 2010 (e delle successive revisioni 2014 e 2015) prodotta dall’ISCO3 – International Scientific Committee of Ozone Therapy, composta da 38 associazioni nazionali e internazionali di ozono e dal documento internazionale “Ozonoterapia basata sull’Evidenza” prodotto nel 2015 dalla WFOT – World Federation of Ozone Therapy, composta da 22 società scientifiche internazionali di ozono terapia.

1- Bocci V. et al. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev.


2- Schwartz A. et al. The Guide for the medical use of ozone. Therapeutic Basis and indications (2011) published


3- Bocci V. Ozone as a bioregulator. Pharmacology and toxicology of ozonotherapy. J. boil. Regul. Homeost. Agents,

  1. 10: 31-53.

4- Pecorelli A. et al. NFR2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial

cells. Toxicol Appl Pharmacol 267, 30-40 (2013)

5- Buckly RD, et al. ozone and human blood. Arch Envir Health 30:40, 19975

6- Poli G. et al. 4-hydroxynonenal: a membrane lipid oxidation product of medical interest. Med. Res. 28:569-631


7- Forman H. et al. Hydrogen peroxide: the good, the bad and the ugly, in Oxidants in Biology (G. Vacchi, and P.

Davis, Eds), Springer, Dordrecht, The Netherlands, pp. 1-17

8- Costanzo M.,et al. Low Ozone Concentrations Stimulate Cytoskeletal Organization, Mitochondrial Activity and

Nuclear Transcription. Eur J Histochem. 2015 Apr 13; 59(2): 2515.

9- Smith NL et al. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med

Gas Res. 2017 Oct 17;7(3):212-219.

10- Valacchi G, Bocci V. Studies on the biological effects of ozone: 11. Release of factors from human endothelial

cells. Mediators Inflamm. 2000;9:271–276.

11- ISCO3. Learning Methodology Instructions and Perfection in Ozone Therapy fo Medical Doctors. wwwisco3.

org (2015)

12- OCEBM. Levels of Evidence Working Group.


13- WFOT’S Review on Evidence Based Ozone Therapy. Comitato scientifico consultivo WFOT (2015)

14- Bocci V. Ozone a new medical drug, 295 (Springer, Dordrecht, The Nederlands, 2005)

15- Berman Jesse D.,et al. Health Benefits from Large-Scale Ozone Reduction in the United States. Environ Health

Perspect. 2012 Oct; 120(10): 1404–1410. Published online 2012 Jul 18.

16- Akin Y et al. Does medical ozone increase the pleurodesis effectiveness of autologous blood? Turk Gogus Kalp

Dama 2016;24(4):736-740

17- Souza YM et al. Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in

rats. Clinics (Sao Paulo). 2010 Feb;65(2):195-202.


18- Travagli V. et al. Ozone and ozonated oils in skin diseases: a review. Hind Pub Corp, Mediators of Inflammations,

Vol 2010, Art ID 610418

19- Kazancioglu HO, Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen

Planus.Ann Dermatol. 2015 Oct;27(5):485-91

20- AEPROMO, The guide for the medical use of ozone. Therapeutic basis and indications (2011).

21- Bocci V et al. Proposta per un corretto procedimento di autoemoterapia ozonizzata, Emma Borrelli- Edictrice

UNI Service.

22-Bocci V. et al. Studies on the biological effects of ozone-5. Evaluation of immunological parameters and tolerability

in normal volunteers receiving ambulatory autotherapy. Biotherapy, vol 7, 1994,pp 8-90

23-Muto M. intradiscal and intramuscular injection of oxygen-ozone: pathological evaluation. Rev Ital Ossigeno

ozono Ter 3, 7-13 (2004)

24- D’Ambrosio CM. Terapia delle IBD mediante Ozonoterapia per via rettale. Rivista Italiana di Ossigeno-Ozono


25- Ansede Alonso AJ et l. Prospective and randomized study in patients with low back pain or sciatic pain ozonotherapy

treatment. Patologia del aparato Locomotor 2007, 5: 46-54

26- Borrelli E. Mechanism of action of oxygen ozone therapy in the treatment of disc herniation and low back pain.

Acta neurochir Suppl 2011;108:123-125.

27- Bonetti M et al. Percutaneos paravertebral ozone therapy. Riv Neurorad 2002;15:415-9.

28-Andreula C et al. Interventional spinal procedures. Eur J Radiol 50, 112-9 (2014)

29-Leonard M. Disc puncture under fluoroscopic guidance. Riv Ital Ossigeno Ozono Ter 1, 73-8 (2002).

30- Fabris G et al. L’ossigeno-ozono terapia intra-foraminale. Rivista di Neuroradiologia 2001; 14:61-6.

31- Lopes de Jesus CC et al. Comparison between intra-articolar ozone and placebo in the treatment of knee osteoarthritis:

a randomized, double-blinded, placebo-controlled study. PLoS One; 201712(7):e0179185.

32- Duplà GR et al. La Ozonoterapia en el tratamiento de las ulceras cronicas de las extremidades inferiors. Riv

Angiologia 02/91.

33- Matassi R et al. Impiego dell’O3 nella terapia delle lipodistrofie distrettuali. Minerva Mesoterapeutica, Vol 2,

N 1 pag 1-6.

34- Rivera Soto M.A. et al. Tratamiento con Ozonoterapia Médica vía Insuflación Vaginal, en paciente femenina

mexicana infectada con VPH 16,18. Reporte de caso Revista Española de Ozonoterapia vol. 7, n° 1. pp. 111-120,


35- Yarustovskaya OV, et al. Ozonotherapy as an efficient component of the combined treatment of the patients

presenting with bacterial vaginosis. Vopr Kurortol Fizioter Lech Fiz Kult. 2015 Sep-Oct;92(5):45-49.

36- Pogosov VS, et al. Medical ozone in combination with low-frequency ultrasound therapy in the treatment of

patients with chronic purulent otitis media. Vestn Otorinolaringol. 2001;(5):24-5.

37- Sin’kov EV.Treatment of patients with acute and chronic suppurative middle ear diseases using ozone preparations.

Vestn Otorinolaringol. 2009;(3):34-5.

38- Sanmez O et al. The evaluation of ozone and betahistine in the treatment of tinnitius. Eur Arch Otorhinolaryngol;

2013 Jul; 270 (7):199-2006.


39- Holz O, et al. Repeated ozone exposures enhance bronchial allergen responses in subjects with rhinitis or

asthma. Clin Exp Allergy. 2002 May;32(5):681-9.

40- Zhang Y, et al. Clinical observation on O3 acupoint injection for treatment of low back pain. Zhongguo Zhen

Jiu. 2007 Feb;27(2):115-6.

41-Tara F et al. Effects of ozonated olive oil and clotrimazole cream of treatment of vulvovaginal candidiasis. Altern

Ther Health Med; 2016 Jul; 22(4),44-9.

42-Patel PV at al. Cytological assessment of healing palatal donor sete wounds and grafted gingival wounds afeter

application of ozonated oil: an eighteen-month randomized controllated clinical trial. Acta Cytol;2012; 56(3):277-


43-Lynch E. Evidence based efficacy of ozone for root canal irrigation. J Esthet Restor Dent 20, 287-93 (2008)

44-Holmes J et al. Clinical reversal of root caries using ozone, double-blind, randomized, controlled 18-month trial.

Gerodontology 20, 106-14 (2003).

45- Bocci V. et al. Is it true ozone is always toxic? The end the dogma, Toxicol. Appl. Pharm,acolo. 2016:493-504


46- Zambello A. et al. Safety in ozone therapy. Riv. It. Ossigeno-Ozonot. 2004, 3:25-35

47- Nkhoma E.T. et al. The global prevalence of glucose-6-phosphate dehydrogenase deficy: a systematic review

and meta-analysis. Blood Cells Mol Dis 42, 267-78 (2009)

48- Jerrett M, Burnett RT, Pope CA, 3rd, et al. Long-term ozone exposure and mortality. N Engl J Med.


49- Bocci V, Valacchi G, et al. Studies on the biological effects of ozone: 9. Effects of ozone on human platelets.

Platelets. 1999;10(2-3):110–116

50- Valacchi G, Bocci V. Studies on the biological effects of ozone: 10. Release of factors from ozonated human

platelets. Mediators of Inflammation. 1999;8(4-5):205–209.

51- Kunz D, et al.. Transforming growth factor beta is increased in plasma of patients with hematologic malignancies

after transfusion of platelet concentrates. Transfusion. 1998 Feb;38(2):156–159

52- Andikyan et al, Morphofunctional changes in the placenta after ozone therapy. Bull Exp Biol Med. 2000


53- Ivanckenko VA. Ozone hemo- and antioxidant therapy and endogenous intoxication in gestosis. Lik Sprava.

1999 Oct-Dec;(7-8):130-3.

54- Olempieva et al. Peculiarities of metabolic rearrangement of gas-transporting function of the blood in the

pregnant women under the influence of medical ozone applied in obstetrical practice. Vopr Kurortol Fizioter Lech

Fiz Kult. 2011 Nov-Dec;(6):33-5

55- Silva P.S. et al. Antihypertensive effects exerted by enalapril in mild to moderate hypertension are not associated

with changes in the circulating levels of nitric oxide-related markers. Eur J Clin OPharmacol. 2011


56- Di Girolamo G. et al. The effect of Enalapril on PGI(2) and NO levels in hypertensive patients. Prostaglandins

Leukot Essent Fatty Acids. 2002 May-Jun;66(5-6):493-8.

57- Bocci V. et al. Oxygen-ozone therapy in medicine: an update, Blood Purif. 28:373-376 (2009)


58- ISCO3. Ozone in non-rheumatic locomotor system pathologies. (2014)

59- Donato A.D: et al The effectiveness of endoscopic epidurolysis in treatmen of degenerative chronic low back

pain: a prospective analysis and follow-up at 48 months. Acta Neurochir Suppl 2011; 108:67-73

60- Magalhaes F.N. et al. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic

review an meta-analysis of randomized controlled trials. Pain Physician. 2012 Ma-Apr;15(2):E115-29

61- Hauanqui C et al. Eficacia y seguridad del ozono intraarticular en artrosis de rodilla refractaria al tratamiento.

Rev. Perù Reum. Vol 12, n 1, 20016. P. 19-24

62- Samper Bernal D et al. Role of intra-articular ozone in osteoartthritis of knee for functional and syntomatic

improvement. Ind J Phys Med Rehabilit 2011;22:65-69

63- Elawamy A. et al. Implication of Two Different Doses of Intradiscal Ozone-Oxygen Injection upon the Pain

Alleviation in Patients with Low Back Pain: A Randomized, Single-Blind Study. Pain Physician. 2018;21(1):25-31

64- Andreula C.F., Simonetti L., De Santis F., Agati R., Ricci R., Leonardi M. Minimally Invasive Oxygen-Ozone Therapy

for Lumbar Disk Herniation AJNR 24; 996-1000, May 2003

65- Andreula CF, Muto M, Leonardi M. Interventional spinal procedures. European Journal of Radiology 2004


66- Bonetti M, et al. Intraforaminal O2-O3 versus periradicular steroidal infiltrations in lower back pain: randomized

controlled study. American Journal of Neuroradiology 2005 26:996-1000.

67- Bonetti M., et al. Ossigeno-ozono terapia vs infiltrazioni epidurali cortisoniche Rivista di Neuroradiologia 13;

203-206, 2000

68- De Santis F, Leonardi M, Simonetti L, Dall’Olio M, Princiotta C, Menetti F. Ossigeno-Ozonoterapia: la tecnica

intradiscale. International Journal of Ozone Therapy 2009 8:138-46.

69- Gallucci M., Limbucci N., et al.Sciatica: Treatment with Intradiscal and Intraforaminal Injections of Steroid and

Oxygen-Ozone versus Steroid Only Radiology. 2007 Mar;242(3):907-13

70- Iliakis E. Ozone treatment in low back pain. Orthopaedics 1: 29-33,1995.

71- Iliakis E., Valadakis V., Vynios D.H., Tsiganos C.P., Agapitos E. Rationalization of the activity of medical ozone

on intervertebral disc and histological and biochemical study. Rivista di Neuroradiologia 14 (suppl.1) 25-30, 2001

72- Lehnert T, Naguib NN, Wutzler S, Nour-Eldin NE, Bauer RW, Kerl JM, Vogl TJ, . Analysis of disk volume before

and after CT-guided intradiscal and periganglionic ozone-oxygen injection for the treatment of lumbar disk herniation.

J Vasc Interv Radiol. 2012 Nov;23(11):1430-6.

73- Leonardi M, Albini Riccioli L, Battaglia S, de Santis F, Cenni P, Raffi L, Simonetti L. Oxygen-ozone chemonucleolysis

for herniated disc with sciatica. A comparison of treatments in patients with subacute and chronic symptoms.

Rivista Italiana di Ossigeno-Ozonoterapia 2006 5:33-6.

74- Leonardi M, Andreula C, Simonetti L. Percutaneous techniques for treating disc disease. Functional Neurology

2003 18:242-4.

75- Leonardi M, Barbara C, Agati R, Simonetti L, Giatti S. Trattamento percutaneo dell’ernia discale lombare con

iniezione intradiscale di miscela di ozono. Rivista di Neuroradiologia 2001 14(Suppl. 1):51-3.

76- Leonardi M, Simonetti L, Barbara C: The effects of the ozone on the nucleous pulposus: pathological data on

one surgical specimen. Rivista di Neuroradiologia 2001 14:57-61.


77- Leonardi M, Simonetti L, Raffi L, Cenni P, Barbara C. Mini-invasive treatment of herniated disc by oxygen-ozone

injection. Interventional Neuroradiology 2003 9(Suppl.2):75

78- Leonardi M., Simonetti L., Barbara C. Effetti dell’ozono sul nucleo polposo: reperti anatomo-patologici su un

caso operato. Rivista di Neuroradiologia 2001 14(Suppl.1):57-9.

79- Muto M, Andreula C, Leonardi M. Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-

ozone (O2-O3) injection. Journal de Neuroradiologie 2004 31:183-9.

80- Pellicanò F. et al. The Italian Oxygen-Ozone Therapy Federation (FIO) study on oxygen-ozone treatment of

herniated disc. International Journal of Ozone Therapy 2007 6:7-15.

81- Rahimi-Movaghar V, Eslami V. The major efficient mechanisms of ozone therapy are obtained in intradiscal

procedures. Pain Physician. 2012 Nov-Dec;15(6)

82- Bonetti M, Intraforaminal O(2)-O(3) versus periradicular steroidal infiltrations in lower back pain: randomized

controlled study.AJNR Am J Neuroradiol. 2005 May;26(5):996-1000

83- Alexandre A Intradiscal injection of oxygen-ozone gas mixture for the treatment of cervical disc herniations.

Acta Neurochir Suppl. 2005;92:79-8

84- Dähnhardt JE Treating sensitive cervical areas with ozone. A prospective controlled clinical trial. Am J Dent.

2008 Apr;21(2):74-6.

85- Oder B. CT-guided ozone/steroid therapy for the treatment of degenerative spinal disease–effect of age, gender,

disc pathology and multi-segmental changes. Neuroradiology. 2008 Sep;50(9):777-85

86- Dall’Olio M, et al. . Oxygen-Ozone Therapy for Herniated Lumbar Disc in Patients with Subacute Partial Motor

Weakness Due to Nerve Root Compression Interventional Neuroradiology 20: 547-554, 2014.

87- Splendiani A, et al. MR assessment of lumbar disk herniation treated with oxygen-ozone diskolysis: the role of

DWI and related ADC versus intervertebral disk volumetric analysis for detecting treatment response. Neuroradiol

  1. 2013 Jun;26(3):347-56.

88- Steppan J, Meaders T, Muto M, Murphy KJ. A metaanalysis of the effectiveness and safety of ozone treatments

for herniated lumbar discs. J Vasc Interv Radiol. 2010 Apr;21(4):534-48.

89- Zhang Y, Ma Y, Jiang J, Ding T, Wang J. Treatment of the lumbar disc herniation with intradiscal and intraforaminal

injection of oxygen-ozone. J Back Musculoskelet Rehabil. 2013;26(3):317-22.

90- Apuzzo D, An observational retrospective/horizontal study to compare oxygen-ozone therapy and/or global

postural re-education in complicated chronic low back pain.Funct Neurol. 2014 Jan-Mar;29(1):31-9.

91- Bocci V. et al. The usefulness of ozone treatment in spinal pain. Drug Des Devel Ther. 2015; 9: 2677–2685.

92- Martınez-Sanchez G et al. Therapeutic efficacy of ozone medical treatments in patients with diabetic foot. Eur

J Pharmacol 2005;523: 151e161

93- Gulmen S, et al. Ozone therapy as an adjunct to vancomycin enhances bacterial elimination in methicillin resistant

Staphylococcus aureus mediastinitis. J Surg Res. 2013;185:64–69.

94- Ragab A, et al. Randomised, double-blinded, placebo-controlled, clinical trial of ozone therapy as treatment

of sudden sensorineural hearing loss. J Laryngol Otol. 2009;123:54–60.

95- Bonforte G, et al. Ozone therapy: a potential adjunct approach to lower urinary tract infection? A case series

report. G Ital Nefrol. 2013;30:gin/30.34.16.

96- Johansson E et al. Antibacterial effect of ozone on cariogenic bacterial species. J Dent. 2009;37:449–53.


97- Bocci V, et al. Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone

therapy. Diabetes Metab Syndr. 2011;5:45–49.

98- Romero Valdés A, et al. Ozone therapy in the advanced stages of arteriosclerosis obliterans. Angiologia.


99- Vinnik IuS . The results of combined ozone therapy using in complex treatment of soft tissues infections in

patients with diabetes mellitus type II].Khirurgiia (Mosk). 2015;(2):63-9. Russian.

100- Abyshov NS,[Prolonged epidural analgesia and ozonated autohemotherapy in complex surgical treatment at

patients with thromboangiitis obliterans and critical limb ischemia].Khirurgiia (Mosk). 2014;(7):82-8

101- Foglieni C,Ozonated autohemotherapy: protection of kidneys from ischemia in rats subjected to unilateral

nephrectomy.BMC Nephrol. 2011 Nov 14;12:61

102- Di Paolo N et al. Necrotizing fasciitis successfully treated with extracorporeal blood oxygenation and ozonization

(EBOO) in man. Int. J. Artif Organs 23:131-141 (2005)

103- Chang JD, et al. Ameliorative effect of ozone on cytokine production in mice injected with human rheumatoid

arthritis synovial fibroblast cells. Rheumatol Int. 2005;26:142–151

104- Bell ML, et al. A meta-analysis of time-series studies of ozone and mortality with comparison to the National

Morbidity, Mortality, and Air Pollution Study. Epidemiology. 2005;16(4):436–445.

105- D’Ambrosio C. M. Trattamento delle malattie infiammatorie croniche dell’intestino mediante ossigeno-ozonoterapia,

Riv. Ital. Ossigeno Ozonoterapia 1:155-158 (2002)

106- Elvis A. M et al. Ozone therapy: A clinical review. J Nat Sci Biol Med. 2011 Jan-Jun; 2(1): 66–70.

107- Kal A, et al. The protective effect of prophylactic ozone administration against retinal ischemia-reperfusion

injury. Cutan Ocul Toxicol. 2017;36:39–47.

108- Beeh KM, et al. Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic

reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical

cross-over-trial. Pulm Pharmacol Ther. 2006;19:233–41.

109-Lintas G et al. Long-term cerebrovascular reactivity mediated by ozone autohemotherapy: a NIRSS study. GNB

2012,June 26th-29th 2012,Rome,Italy

110- Di Filippo C, et al. Daily Oxygen/O3 Treatment Reduces Muscular Fatigue and Improves Cardiac Performance

in Rats Subjected to Prolonged High Intensity Physical Exercise. Oxid Med Cell Longev. 2015; 2015: 190640.

111- Bocci V. Does ozone therapy normalize the cellular redox balance? Implications for the therapy of human

immunodeficiency virus infection and several other diseases. Medical Hypotheses. 1996;46(2):150–154.

112- Bell M. L.,et al. Who is More Affected by Ozone Pollution? A Systematic Review and Meta-Analysis. Am J

Epidemiol. 2014 Jul 1; 180(1): 15–28.

113- Szyszkowicz M, et al. Ambient ozone and emergency department visits for cellulitis. Int J Environ Res Public

Health. 2010;7(11):4078–4088.

114- Sönmez O The evaluation of ozone and betahistine in the treatment of tinnitus. Eur Arch Otorhinolaryngol.

2013 Jul;270(7):1999-2006

115- Taşdemir Z, The Effects of Ozone Therapy on the Early Healing Period of De-epithelialized Gingival Grafts: A

Randomized Placebo-controlled Clinical Trial.J Periodontol. 2016 Jan 16:1-17


116- Clavo B,.Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer

Patients. Evid Based Complement Alternat Med. 2015;2015:480369

117- Vanni D. Intraforaminal ozone therapy and particular side effects: preliminary results and early warning. Acta

Neurochir (Wien). 2016 Mar;158(3):491-6

118- Doğan M, Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related

pain.Med Princ Pract. 2014;23(6):507-10.

119- Kazancioglu HOEffects of ozone therapy on pain, swelling, and trismus following third molar surgery.Int J Oral

Maxillofac Surg. 2014 May;43(5):644-8

120- Patel PV. Evaluation of ozonated olive oil with or without adjunctive application of calcium sodium phosphosilicate

on post-surgical root dentin hypersensitivity: a randomized, double-blinded, controlled, clinical trial.Minerva

Stomatol. 2013 May;62(5):147-61

121- Kazancioglu HO Comparison of the influence of ozone and laser therapies on pain, swelling, and trismus

following impacted third-molar surgery. Lasers Med Sci. 2014 Jul;29(4):1313-9

122- Clavo B, Brain ischemia and hypometabolism treated by ozone therapy. Forsch Komplementmed.


123- Fuccio C, A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of

pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice. Eur J Pharmacol. 2009 Jan 28;603(1-


124- Azarpazhooh A, Evaluating the effect of an ozone delivery system on the reversal of dentin hypersensitivity:

a randomized, double-blinded clinical trial. J Endod. 2009 Jan;35(1):1-9

125- Rickard GD, Ozone therapy for the treatment of dental caries. Cochrane Database Syst Rev.


126- Białoszewski D.The use of the intraooperative ozone – theraphy as prophylaxis of infections in surgery of

locomotor system with special regard to total hip plasty – a preliminary study. Ortop Traumatol Rehabil. 2003 Dec


127- Hidalgo-Tallon et al. Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation:

an open-label pilot study. J Altern Complement Med. 2013 Mar;19(3):238-42. doi: 10.1089/acm.2011.0739. Epub

2012 Oct 9.

128- Chernyshev AL, et al. Combined treatment including ozonotherapy of patients with viral hepatitis. Vopr Kurortol

Fizioter Lech Fiz Kult. 2008 May-Jun;(3):19-22

129- Vaughn JM, et al. Effects of ozone treatment on the infectivity of hepatitis A virus. Can J Microbiol. 1990


130- Aslan MK et al. Protective effect of intraperitoneal ozone application in experimental ovarian ischemia/reperfusion

injury. J Pediatr Surg. 2012 Sep;47(9):1730-4.

131- Muzi, F., and Tati, G. Oxygen-Ozone Autohaemotherapy and Intravescical Oxygen-Ozone Insufflations in

Treatment of Recurrent and Interstitial Cystitis: Preliminary Results. Journal of Pharmacy and Pharmacology 5

(2017) 512-4 doi:10.17265/2328-2150/2017.08.004

132- Hussain S et al. Intraprostatic ozone therapy: A minimally invasive approach in benign prostatic hyperplasia.

Urol Ann. 2017 Jan-Mar;9(1):37-40. doi: 10.4103/0974-7796.198843.


133 -Valacchi G. Fortino V. Bocci V. The dual action of ozone on the skin British J. of Dermatology Vol. 153 Issue 6

dec 2005: 1096-1100

134- Giombini A et al. Comparison between intrarticular injection of hyaluronic acid, oxygen ozone, and the combination

of both in the treatment of knee osteoarthrosis. J Biol Regul Homeost Agent. 2016 Apr-Jun; 30(2):621-5

135- Lopes de Jesus CC et al. Comparison between intra-articular ozone and placebo in the treatment of knee

osteoarthritis: A randomized, double-blinded, placebo-controlled study. PLoS One. 2017 Jul 24;12(7):e0179185.

doi: 10.1371/journal.pone.0179185. eCollection 2017

136- Martinelli M et al. Water and air ozone treatment as an alternative sanitizing technology.J Prev Med Hyg.

2017 Mar;58(1):E48-E52

137 – Cannizzaro A. et al. O2O3 Exposure inhibits cell progression affecting cyclin B1/cdk1 activity in SK-N-SK while

induced apoptosis in SK-N-DZ neuronal stoma cells. JCP 9999:1-11,2007

138 – Amendola D. et al. Ozone treatment does not induced toxicity in human NIH3T3 fibroblast cells. Int J Ozone

therapy 7:1318,2008

139 – Kuroda K et al. The safety and anti-tumor effect of ozonated water in vivo. Int J Mol Sci. 16,25108-25120,2015